Inhibition by soluble ribonucleic acid of stimulatory effect of liver template ribonucleic acid
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چکیده
منابع مشابه
The inhibition of liver ribonucleic acid synthesis by ethionine.
The administration of DL-ethionine to female rats inhibits liver ribonucleic acid synthesis up to 90 to 95%. The inhibition of RNA synthesis follows in time the decrease in adenosine triphosphate concentration and precedes the inhibition of protein synthesis. The degree of inhibition of RNA synthesis is a function of the dose of ethionine. The curve for this inhibition parallels closely the cur...
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The MO-formyltetrahydrofolate:methionyl soluble ribonucleic acid transformylase has been purified over 1500-fold from Escherichia coli B. Although not homogeneous at this stage, the enzyme was of sufficient purity to determine some physical characteristics. The sedimentation constant was 2.02 which would indicate a molecular weight of approximately 25,000. In addition to the substrates of the r...
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merase (EC 2.7.7.6) have been demonstrated in eukaryotic cells (Roeder & Rutter, 1969; Jacob et al., 1970a; Kedinger et al., 1970; Mondal et al., 1970; Horgen & Griffin, 1971; Strain et al., 1971). RNA polymerase I (or A), which is associated with the nucleolus (Roeder & Rutter, 1970), is probably engaged in the transcription of nucleolar genes to form rRNA (Blatti et al., 1970; Tocchini-Valent...
متن کاملSpecies Specificity of Amino Acid Acceptor Ribonucleic Acid and Aminoacyl Soluble Ribonucleic Acid Synthetases.
Several investigators have reported that the activation of amino acids for protein synthesis, i.e. the incorporation of amino acids into soluble ribonucleic acids, is dependent upon the source of both the aminoacyl S-RNA’ synthetases and the S-RNA itself. For example, Rendi and Ochoa (1) reported that aminoacyl S-RNA synthetases from Escherichia coli could not incorporate leucine into yeast or ...
متن کاملStudies on Soluble Ribonucleic Acid of Rabbit Liver
The discovery that soluble ribonucleic acid can function as an acceptor of activated amino acids and as an intermediate in the transfer of activated amino acids into microsomal protein (1) suggests that this nucleic acid performs a key function in the process of protein biosynthesis (2). Structural and functional studies have shown that soluble ribonucleic acid is quite homogeneous with respect...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1966
ISSN: 0006-2936
DOI: 10.1042/bj1010448